opinion, poetry

The Three Days of Darkness … in a poetry challenge

Maybe it’s the world’s mode these days; can’t help to think of a Catholic popular prophecy in which the stage is being set right now! My opinion only, of course! Prophecy is “The Three Days of Darkness.”
Linda Kruschke has inspired this writing with the words this week contained in her Paint Chip challenge.

Presenting the Paint Chips, please join in with your creative writing.

The time is now; that Grand Plan
Prep, don’t forget stock a drink
Juice, maybe freshly squeezed, — please!
Make sure your plan is at hand.

A rainstorm of fire will form
Wishing life — under the sea.
The dead, we will all envy.
God deliver us, our plea!

Attach to God or detached?
Winds roll us as tumbleweeds.
Where O’where rosary beads?
Never late, long as we breathe.

Tongue-tied fear viewing sunsets!
Green flashes for all to see.
When it’s over, sun to rise.
A world becomes very wise.

Now to know the Master’s sign.
Every knee bends at His name.
The world; a canvas so blank
We have God’s mercy to thank.

#FOWC, Just Because, opinion

What If !!!

The word today from the famous Fandango is PERFUNCTORY!

Fight with delight, fight the fight, these statues the “peaceful” unthinking, perfunctory protestors are tearing down, have had enough.  BEWARE!

You will have to agree, I feel, these images below are certainly perfunctory, glib, or at least artful, depending on how you look at things.

 

 

 

 

 

 

 

 

 

 

 

opinion, Wordle

For what its WORTH … to You!

The Wordle of WORDS are:

My first thought was to PASS on this wordle, yet, my brain quickly turned to the MAINSTREAM NEWS known as those who brown noses or PANDER to one side! As SHOCKing seems to some, in reality, they are DESIGNed that you and I FALL in LINE!
FILL the gap with inconsistency is the method of operation.
Many come to America because they COVET the USA; some come to dishonor our STRIPES of red, white, and blue. Their ears only hear the WILD fake news of the PRESS who MINE but can’t find the dirt they seek.
Thank God for the great awakening and 4 more years of Truth, Justice, and the American way.

Just Because, opinion

Is Melatonin the answer to the corona crisis?

Melatonin is the reason why children under the age of 9 seldom exhibit severe symptoms. In fact, children may exhibit mild or even no symptoms at all, even though they have been infected by SARS-CoV-2 [73].  How significant is the difference in melatonin production between children, adults and the elderly?

For most people, peak melatonin production is between the hours of 2 am to 3 am.  The maximum melatonin levels measured in healthy adults between the ages of 65 to 70 years appeared to be around 49.3 picograms/ml (pg/ml).  Adults more than 75 years of age only have maximum production levels of 27.8 pg/ml [74].

Young children, on the other hand, have extremely high melatonin levels, compared to adults.  The maximum levels recorded for children showed a decline as age increased. Children between the ages of 1 to 5 had peak melatonin at 325 pg/ml, while those between the ages of 5 to 11 already declined to 133 pg/ml [76].

Compared to healthy adult seniors, a young child can easily have TEN TIMES the amount of peak melatonin levels.  But even then, the actual physiological concentration is extremely low. How much is one picogram, exactly?

To give you some perspective, most melatonin supplements are around 3 to 5 mg per capsule or tablet.  One milligram equals 1,000,000,000 picograms. That is why the physiological dosage generally recommended for melatonin supplementation is around 0.3 milligrams [75].

The fact that young children have such high melatonin levels explains why they show very mild symptoms after COVID-19 infections.

 

Melatonin is a potent inhibitor of NLRP3 inflammasomes.

Generally referred to as the “hormone of darkness”,  the ability of melatonin to regulate both pro- as well as anti-inflammatory cytokines in different pathophysiological conditions has only been extensively studied in the past several years.

Controlling cytokine storms is one of the major challenges in the treatment of sepsis [82].  The NLRP3 inflammasome has an interesting nickname of “Pandora’s Box for Sepsis” [83]. Yet nature provides all the solutions to difficult health challenges.

NLRP3 inflammasomes is a direct target of melatonin.  Animal models of sepsis showed melatonin’s ability to maintain mitochondrial homeostasis, reduce reactive oxygen species and lower production of proinflammatory cytokines. Melatonin was shown to inhibit NLRP3 inflammasomes in mice with myocardial septic conditions, transforming severe myocardial inflammation into milder symptoms, preventing cardiac failure, and significantly enhanced survival rates of septic mice [77, 78].

An excellent study by Volt et al (2016) showed that chronic low doses of melatonin in aged mice could prevent increase in inflammation, ROS and mitochondria impairments reflective of inflammaging [79, 80]. Volt et al. also showed that acute administration of melatonin could counteract severe inflammatory responses [81].

It is therefore not surprising to find that melatonin is able to prevent ARDS/ALI through suppression of NLRP3 inflammasomes.

In rodent acute lung injury (ALI) models, melatonin was found to markedly reduce pulmonary injury, lower infiltration of macrophages and neutrophils into lungs. Melatonin protected mice from acute lung injuries by inhibiting the activation of NLRP3 inflammasomes through the suppression of extracellular release of histones and blocking histone-induced NLRP3 inflammasome activation [84].

In rodent models of acute respiratory distress syndrome (ARDS), combined treatment of melatonin and mitochondria significantly attenuated progression of ARDS [85].

Melatonin Protects Lung Injury from Mechanical Ventilation Interventions

COVID-19 patients with ARDS/ALI often require intubation with mechanical ventilation.  Even though the intervention may help patients, in many instances, patients develop ventilator-induced lung injury as a result of mechanical ventilation [86].  In particular, high ventilation pressures and high tidal volumes required to maintain proper oxygenation and CO2 elimination can cause lung damage and impair gas exchange.

A study released on March 6, 2020 by Geng-Chin Wu et al. demonstrated that by increasing melatonin with the use of a melatonin receptor agonist, damaging effects of ventilator-induced lung injury could be prevented in rodent models [87].

The full therapeutic potential of melatonin in its ability to modulate the immune system, especially the critical function of suppressing cytokine storms to prevent progression of acute respiratory distress syndrome (ARDS) and respiratory failure in infected patients was clearly demonstrated in a study by Huan]g et al. (2019).  Huang et al. infected rodents with the highly lethal and infectious H1N1 influenza A virus. Co-treatment of these infected rodents with melatonin and an antiviral drug significantly increased their survival rates compared to mice treated only with antivirals alone [88]!

It is no wonder that none of the pregnant mothers infected by COVID-19  admitted to Zhongnan Hospital of Wuhan University, Wuhan, China,  developed severe pneumonia or died; nor were their babies infected by COVID-19 [89]. Why?

Melatonin secretion in the third trimester of pregnancy is more than doubled compared to the first trimester.

COVID-19, Pneumonia & Inflammasomes – The Melatonin Connection

#FOWC, opinion, Politics

The Truth why they Hate! (my opinion) What is yours?

They are not even being SUBTLE about it!  Why the hate?  He cramps their agenda!

 

Fellow voters, do you want to vote for those who are not interested in Truth, Justice, or the American Way. Their agenda is GLOBALISM, which is tantamount to slavery, as slavery the opposite of freedom.    

What goes along with Globalism is a One World Religion! Is that your vote! You agree, instead of your faith or no faith, you are willing to put it aside to accept “their” beliefs, whether you believe it or not. 

Educate yourself, research, and study up!