Ah! Another Challenge, Mindlovesmisery's, poetry

Why are we here? Welsh Poetry

What a challenge!  I tried!  See below

Rhupunt is a Welsh poetry form. Here are the guidelines for the rhupunt:

  • The form can be broken down into lines or stanzas
  • Each line or stanza contains 3 to 5 sections
  • Each section has 4 syllables
  • All but the final section rhyme with each other
  • The final section of each line or stanza rhymes with the final section of the other lines or stanzas

*******************

 

why are we here
to drink a beer
to add some cheer
a bad omen

seek a good friend
but learn to bend
stretch to the end
write a poem

keep it simple
nothing sinful
see the steeple
you’re almost home

dVerse, poetry, Word Prompts

How it Will End— Depends on ME!

Linked to dVerse Open Link

Here we are again; time to paint a little, our paint chips can be viewed below.

This is How it will End

The Journey, we are within —
Yesterday, like the first kiss
never again!

Bygone the golden hour of the past —
Wasted? Melted as an ice cap
Nevermore!

Will eternity be sipping amethyst wine
and camomile tea relaxing on soft clouds
or

Dodging hot pink, habanero flames
Continually seeking to devour!

How it will end depends on me!   

Eternity

 

poetry, Word Prompts

A Little Advice on True Love

What a Challenge this time for me, it was indeed!  

A Little Bit of Advice about True Love

 

True Love is not ever-changing as an inchworm
After the fire, is a hot potato — affirmed

To love is to serve, as a sunflower serves God
Testing love by a mistletoe — certainly odd

Grapefruits quite sour, as well as wild mushroom, are chance
When he’s willing to serve you, its time for romance

 

Join the Prompt by clicking

HERE

FFFC, Uncategorized

The Talking Tree — Speaking to Thee

A Flash-Fiction inspiration:

The prompt image and perception remind us of the present and past. The trunk of the tree represents the NOW; the top represents the past. Nature is finding a voice to explain as time goes by, things seem to thin out, situations are no longer excessive as when looking directly at them, seeing them from a distance they become surrounded; strangled/tangled with different happenings in our past life.
Is the top of the tree the beginning of life or the end? That may depend on how we look at it. Do we still have a purpose, or have we fulfilled it? Do we have regrets or content?

One day while strolling in the park and passing this tree so many times, I saw it for the first time. I wanted to climb it, so I did. When I reached the very top, after being scratched from head to toe with snarly branches and prickly bits, I looked down below from where I started. Everything below seemed so real beckoning me to hurry back. Suddenly I began to fall, down, down; I tried to grab on to the past, but could not. The force of gravity was in full force, seeing the ground getting closer and closer, shut my eyes; waited for the slam. Got up and shook off the remnants of my past, what a Wake-Up! I got up, examined my life, and vowed from that day on to find my purpose in life and fulfill it, starting with obeying the Ten Commandments of God.

 

311D3216-9BF1-40D8-A33A-332B86049E8B

Just Because, opinion

Is Melatonin the answer to the corona crisis?

Melatonin is the reason why children under the age of 9 seldom exhibit severe symptoms. In fact, children may exhibit mild or even no symptoms at all, even though they have been infected by SARS-CoV-2 [73].  How significant is the difference in melatonin production between children, adults and the elderly?

For most people, peak melatonin production is between the hours of 2 am to 3 am.  The maximum melatonin levels measured in healthy adults between the ages of 65 to 70 years appeared to be around 49.3 picograms/ml (pg/ml).  Adults more than 75 years of age only have maximum production levels of 27.8 pg/ml [74].

Young children, on the other hand, have extremely high melatonin levels, compared to adults.  The maximum levels recorded for children showed a decline as age increased. Children between the ages of 1 to 5 had peak melatonin at 325 pg/ml, while those between the ages of 5 to 11 already declined to 133 pg/ml [76].

Compared to healthy adult seniors, a young child can easily have TEN TIMES the amount of peak melatonin levels.  But even then, the actual physiological concentration is extremely low. How much is one picogram, exactly?

To give you some perspective, most melatonin supplements are around 3 to 5 mg per capsule or tablet.  One milligram equals 1,000,000,000 picograms. That is why the physiological dosage generally recommended for melatonin supplementation is around 0.3 milligrams [75].

The fact that young children have such high melatonin levels explains why they show very mild symptoms after COVID-19 infections.

 

Melatonin is a potent inhibitor of NLRP3 inflammasomes.

Generally referred to as the “hormone of darkness”,  the ability of melatonin to regulate both pro- as well as anti-inflammatory cytokines in different pathophysiological conditions has only been extensively studied in the past several years.

Controlling cytokine storms is one of the major challenges in the treatment of sepsis [82].  The NLRP3 inflammasome has an interesting nickname of “Pandora’s Box for Sepsis” [83]. Yet nature provides all the solutions to difficult health challenges.

NLRP3 inflammasomes is a direct target of melatonin.  Animal models of sepsis showed melatonin’s ability to maintain mitochondrial homeostasis, reduce reactive oxygen species and lower production of proinflammatory cytokines. Melatonin was shown to inhibit NLRP3 inflammasomes in mice with myocardial septic conditions, transforming severe myocardial inflammation into milder symptoms, preventing cardiac failure, and significantly enhanced survival rates of septic mice [77, 78].

An excellent study by Volt et al (2016) showed that chronic low doses of melatonin in aged mice could prevent increase in inflammation, ROS and mitochondria impairments reflective of inflammaging [79, 80]. Volt et al. also showed that acute administration of melatonin could counteract severe inflammatory responses [81].

It is therefore not surprising to find that melatonin is able to prevent ARDS/ALI through suppression of NLRP3 inflammasomes.

In rodent acute lung injury (ALI) models, melatonin was found to markedly reduce pulmonary injury, lower infiltration of macrophages and neutrophils into lungs. Melatonin protected mice from acute lung injuries by inhibiting the activation of NLRP3 inflammasomes through the suppression of extracellular release of histones and blocking histone-induced NLRP3 inflammasome activation [84].

In rodent models of acute respiratory distress syndrome (ARDS), combined treatment of melatonin and mitochondria significantly attenuated progression of ARDS [85].

Melatonin Protects Lung Injury from Mechanical Ventilation Interventions

COVID-19 patients with ARDS/ALI often require intubation with mechanical ventilation.  Even though the intervention may help patients, in many instances, patients develop ventilator-induced lung injury as a result of mechanical ventilation [86].  In particular, high ventilation pressures and high tidal volumes required to maintain proper oxygenation and CO2 elimination can cause lung damage and impair gas exchange.

A study released on March 6, 2020 by Geng-Chin Wu et al. demonstrated that by increasing melatonin with the use of a melatonin receptor agonist, damaging effects of ventilator-induced lung injury could be prevented in rodent models [87].

The full therapeutic potential of melatonin in its ability to modulate the immune system, especially the critical function of suppressing cytokine storms to prevent progression of acute respiratory distress syndrome (ARDS) and respiratory failure in infected patients was clearly demonstrated in a study by Huan]g et al. (2019).  Huang et al. infected rodents with the highly lethal and infectious H1N1 influenza A virus. Co-treatment of these infected rodents with melatonin and an antiviral drug significantly increased their survival rates compared to mice treated only with antivirals alone [88]!

It is no wonder that none of the pregnant mothers infected by COVID-19  admitted to Zhongnan Hospital of Wuhan University, Wuhan, China,  developed severe pneumonia or died; nor were their babies infected by COVID-19 [89]. Why?

Melatonin secretion in the third trimester of pregnancy is more than doubled compared to the first trimester.

COVID-19, Pneumonia & Inflammasomes – The Melatonin Connection

FFE, Word Prompts

How to be Happy, Healthy and Holy

Life, what is our purpose of being here? In today’s world, unfortunately, it means doing whatever we want.

If we are honest with ourselves and examine our conscience, we will admit the above idea does not bring us happiness, only unhappiness.
We are merely as the saying goes, “Barking up the wrong tree” or not looking in the right direction for peace of soul and happiness.
Humanity, for all times, is given Ten Commandments to follow: the influence of this world say they are only suggestions.

How is putting the Ten Commandments on the back burner working out for you? Do you know the

                                                                         OR

“Not doing well today, “Take a pill.” There are pills today for everything under the sun. Medicines to help your state of mind, pills to keep you awake or fall asleep. Some tablets help you lose weight, or cope as struggling through the day Etc. Etc.  Indeed!  Medicines are gifts of God, not to be abused or replaced with truth.  Ask and you shall find!  Remember in the end God gives us our desires as we lived them.

Could it POSSIBLY be that WE are BARKING UP THE WRONG TREE?  Realizing I have been there done that!