The Wordle of WORDS are:
Melatonin is the reason why children under the age of 9 seldom exhibit severe symptoms. In fact, children may exhibit mild or even no symptoms at all, even though they have been infected by SARS-CoV-2 . How significant is the difference in melatonin production between children, adults and the elderly?
For most people, peak melatonin production is between the hours of 2 am to 3 am. The maximum melatonin levels measured in healthy adults between the ages of 65 to 70 years appeared to be around 49.3 picograms/ml (pg/ml). Adults more than 75 years of age only have maximum production levels of 27.8 pg/ml .
Young children, on the other hand, have extremely high melatonin levels, compared to adults. The maximum levels recorded for children showed a decline as age increased. Children between the ages of 1 to 5 had peak melatonin at 325 pg/ml, while those between the ages of 5 to 11 already declined to 133 pg/ml .
Compared to healthy adult seniors, a young child can easily have TEN TIMES the amount of peak melatonin levels. But even then, the actual physiological concentration is extremely low. How much is one picogram, exactly?
To give you some perspective, most melatonin supplements are around 3 to 5 mg per capsule or tablet. One milligram equals 1,000,000,000 picograms. That is why the physiological dosage generally recommended for melatonin supplementation is around 0.3 milligrams .
The fact that young children have such high melatonin levels explains why they show very mild symptoms after COVID-19 infections.
Melatonin is a potent inhibitor of NLRP3 inflammasomes.
Generally referred to as the “hormone of darkness”, the ability of melatonin to regulate both pro- as well as anti-inflammatory cytokines in different pathophysiological conditions has only been extensively studied in the past several years.
Controlling cytokine storms is one of the major challenges in the treatment of sepsis . The NLRP3 inflammasome has an interesting nickname of “Pandora’s Box for Sepsis” . Yet nature provides all the solutions to difficult health challenges.
NLRP3 inflammasomes is a direct target of melatonin. Animal models of sepsis showed melatonin’s ability to maintain mitochondrial homeostasis, reduce reactive oxygen species and lower production of proinflammatory cytokines. Melatonin was shown to inhibit NLRP3 inflammasomes in mice with myocardial septic conditions, transforming severe myocardial inflammation into milder symptoms, preventing cardiac failure, and significantly enhanced survival rates of septic mice [77, 78].
An excellent study by Volt et al (2016) showed that chronic low doses of melatonin in aged mice could prevent increase in inflammation, ROS and mitochondria impairments reflective of inflammaging [79, 80]. Volt et al. also showed that acute administration of melatonin could counteract severe inflammatory responses .
It is therefore not surprising to find that melatonin is able to prevent ARDS/ALI through suppression of NLRP3 inflammasomes.
In rodent acute lung injury (ALI) models, melatonin was found to markedly reduce pulmonary injury, lower infiltration of macrophages and neutrophils into lungs. Melatonin protected mice from acute lung injuries by inhibiting the activation of NLRP3 inflammasomes through the suppression of extracellular release of histones and blocking histone-induced NLRP3 inflammasome activation .
In rodent models of acute respiratory distress syndrome (ARDS), combined treatment of melatonin and mitochondria significantly attenuated progression of ARDS .
Melatonin Protects Lung Injury from Mechanical Ventilation Interventions
COVID-19 patients with ARDS/ALI often require intubation with mechanical ventilation. Even though the intervention may help patients, in many instances, patients develop ventilator-induced lung injury as a result of mechanical ventilation . In particular, high ventilation pressures and high tidal volumes required to maintain proper oxygenation and CO2 elimination can cause lung damage and impair gas exchange.
A study released on March 6, 2020 by Geng-Chin Wu et al. demonstrated that by increasing melatonin with the use of a melatonin receptor agonist, damaging effects of ventilator-induced lung injury could be prevented in rodent models .
The full therapeutic potential of melatonin in its ability to modulate the immune system, especially the critical function of suppressing cytokine storms to prevent progression of acute respiratory distress syndrome (ARDS) and respiratory failure in infected patients was clearly demonstrated in a study by Huan]g et al. (2019). Huang et al. infected rodents with the highly lethal and infectious H1N1 influenza A virus. Co-treatment of these infected rodents with melatonin and an antiviral drug significantly increased their survival rates compared to mice treated only with antivirals alone !
It is no wonder that none of the pregnant mothers infected by COVID-19 admitted to Zhongnan Hospital of Wuhan University, Wuhan, China, developed severe pneumonia or died; nor were their babies infected by COVID-19 . Why?
Melatonin secretion in the third trimester of pregnancy is more than doubled compared to the first trimester.
Regularly I tune into the live earthquake website and Dutchsinse on Youtube. Lately, there is a severe showing of activity near the crater known as the Pisgah Crater Volcano. For those yet to be introduced to Dutchsinse and his predictions and No he is not a prophet, just a young regular guy who discovered a unique scientific way of forecasting earthquakes. A little about Dutch; his fundamental discovery based on science which is why the “experts” hate him.
Getting back to my interest in this Pisgah Crater Volcano is because it seems it might be an awakening of a small volcano there in Ludlow Calif.
Not sure if the readers have been following since the mainstream news spends most of their time spinning the earthquakes that are ongoing in the world of politics. Brainwashing those who can’t think, but only obey those who preach bunkum.
Getting back to: Have you realized today about 1,500 potentially active volcanoes worldwide, which reminds me of this verse: “And there shall be great earthquakes in divers places, and pestilences, and famines, and terrors from heaven; and there shall be great signs.”[Luke 21:11]
Living today, in my opinion, is undoubtedly lively!
#FPQ His question of the week and my answer or opinion whatever the reader wants to believe.
“Do you believe that size matters? Please explain your response.”
I have discovered when I do my grocery shopping in the produce section, the smaller the banana, tomato, onion, watermelon or whatsoever, the sweeter the taste. Maybe it’s just my imagination! Having posted that I think size does matter. Consider also: “The bigger they are, the harder they fall.” I am concerned since my son is 6’5″ … ouch! Love him anyway!
Majority or minority also come to mind, reminding me of a quote I read many years ago, I don’t remember who’s words, but it was profound. “The majority are at times on the wrong side.” It was similar to this quote here from Mark Twain.
FOWC another blogger here on WordPress always has some exciting prompts to excite our way of thinking. Today the word is “Heretic.”
One can ask a zillion people what heresy is; receive definitions from A to Z with numerous various opinions in between. Example: What is the truth?
God knows the heart and soul of each of us; He knows the opportunity we have been given to know the Truth, He knows if we want His Truth or do we want our truth?
This particular verse in the Apocalypse of the Bible sums it up for me, simple and to the point:
“But because thou art lukewarm, and neither cold nor hot, I will begin to vomit thee out of my mouth.”
[Apocalypse (Revelation) 3:16]